Nick Norwitz MD PhD

How I Lost Weight By Eating 6,000 More Calories

For a written breakdown, early access to content like this, and extra nuances, see the associated StayCurious Metabolism newsletter: https://open.substack.com/pub/staycuriousmetabolism/p/are-we-close-to-unlocking-the-secret?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Winnow Microplastic Binding Probiotic: https://www.winnowlabs.com/STAYCURIOUS25 Use Discount Code “StayCurious” for 15% Off Microplastics Heart Health, Letter https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Microplastics Brain Health, Letter: https://staycuriousmetabolism.substack.com/p/this-graph-changed-how-i-think-about?r=40ekz2 Nattokinase Video: https://youtu.be/LGQO227_Mto Description: What if you could burn hundreds of extra calories per day, without changing your exercise routine or activity? It sounds impossible. But controlled human trials suggest that simply lowering protein intake might increase energy expenditure by up to 20%, even when total calories stay the same. In this video, I break down a bizarre and fascinating metabolic story: from human trials showing massive increases in calorie burn, to my own self-experiment where I deliberately overate and still lost weight, to a brand-new paper in Nature that may finally explain what’s going on. The answer leads us to the gut microbiome and reveals a mechanism involving fat “beiging,” thermogenesis, and a specific microbial cocktail that may control how much energy we burn. This is not a recommendation to follow a low-protein diet. It’s an exploration of a surprising scientific phenomenon that challenges how we think about metabolism, and a glimpse into a future where we might be able to engineer fat burning at the biological level. Chapters 0:00 – How to Burn 600 More Calories Per Day 2:48 – Chapter 1: The Most Surprising Study of 2025 5:00 – Chapter 2: My Fat Burning Self-Experiment 7:40 – Chapter 3: The Breakthrough Paper 10:54 – Chapter 4: The Fat-Burning Cocktail 15:40 – Chapter 5: What This Means for Me and You 18:42 – Do Ketogenic Diets Boost Metabolism Too? 21:10 – My Principles of Gut Health #metabolism #fatloss #nutrition #weightloss #science #health #diet #calories #microbiome #guthealth #ketogenicdiet #keto #lowprotein #fatburning #thermogenesis #longevity #biohacking #healthscience #nutritionscience #fitness #metabolichealth #insulin #fatlossjourney #diettips #wellness #research #clinicaltrials #scienceexplained #humanmetabolism #microbiota #probiotics #gutmicrobiome #fasting #intermittentfasting #lowcarb #ketolife #nutritionfacts #healthtips #weightlosstips #fatburn #metabolicrate #energybalance #calorieburning #newscience #healthresearch #medicalscience #physiology #staycurious #n1experiment #biochemistry