Low Cholesterol Won’t Save You. Measure This Instead.

For all the references, extra nuance and early access to content like this, join the Best-Selling in Science StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/beyond-ldl-rethinking-cardiovascular?r=40ekz2 Referenced Content Masterclass on Cholesterol-Lowering Medications, Letter: https://staycuriousmetabolism.substack.com/p/a-concise-masterclass-on-cholesterol?r=40ekz2 Statins Slash GLP-1, Video: https://youtu.be/6NomrgjK1yQ Statins Harms Mitochondria, Video: https://youtu.be/qHXMI3DudEc What Statin Trials Really Show, Video: https://youtu.be/Y3JKgfKqiBQ Statins Associated with Muscle Loss, Letter: https://staycuriousmetabolism.substack.com/p/a-doctor-texted-me-im-stopping-my?r=40ekz2 Lp(a) and Waist-to-Hip Ratio, Video: https://youtu.be/UOtYZ0ZSp24 Description Decades of cardiovascular research have focused on LDL cholesterol as the primary driver of atherosclerosis, yet even individuals with “optimal” LDL often develop arterial plaque. In this video, we examine the limitations of LDL-centric models and highlight why single-biomarker approaches can misrepresent true cardiovascular risk. We break down recent cohort studies, explore critiques of the data, and discuss why broader metabolic factors—insulin resistance, inflammation, triglyceride levels, and visceral adiposity—provide a more complete picture of heart health. Finally, we provide framework for tracking biomarkers that better reflect systemic cardiovascular risk. Chapters 0:00 – Low Cholesterol Isn’t Enough 2:00 – Roadmap to this Video 2:23 – Chapter 1: What Happens When LDL Cholesterol is “Optimal?” 5:00 – Chapter 2: What the Critics Say About the Data 7:17 – Chapters 3: What I Am—and Am Not—Saying 9:23 – Chapter 4: Why Is This Personal? 11:00 – Chapter 5: The “Not Low Enough” Trap in Conventional Cardiology 13:44 – Chapter 6: Science-Based Biomarkers to Track for Heart Health #HeartHealth #LDLCholesterol #Atherosclerosis #MetabolicHealth #InsulinResistance #Statins #CholesterolMyths #CardiovascularRisk #HealthEducation #NickNorwitz #StayCurious