Ezetimibe’s Secret Identity? A Possible New Angle on Alzheimer’s Prevention

LINK: https://open.substack.com/pub/staycuriousmetabolism/p/this-study-completely-changed-how?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true Researchers screened existing medications for their ability to reduce harmful protein clumping in the brain—and unexpectedly, ezetimibe emerged as a hit. The drug crosses the blood–brain barrier, disrupts a protein interaction linked to aggregation, and is associated with less amyloid and tau in experimental models. What's more a patient chart review found an eight-fold lower risk of Alzheimer’s disease. This isn’t a cholesterol story—it’s a brain biology story. For the mechanisms, study limits, and what this really means for prevention, watch the full deep dive linked above. #AlzheimersResearch #Neuroscience #BrainHealth #DrugRepurposing #Amyloid #StayCurious