Disruptores endócrinos em cosméticos: o que sabemos?

#disruptoresendocrinos #cosmeticos #puberdade 00:00 - Introdução 01:13 - O que são disruptores endócrinos? 08:01 - Ftalatos e Parabenos são perigosos? 14:28 - Como os estudos de toxicidade são feitos? 18:55 - Produtos químicos encontrados no sangue 22:20 - A farsa do Clean Beauty 27:04 - Puberdade precoce – o que é? 34:11 - O shampoo é um problema? Roteiro base: Mariella Careaga e Laura Marise Roteiro final: Laura Marise Produção: Laura Marise Edição: Laís Maurelli Design da miniatura: Laura Marise Legendas: Beatriz Pinheiro Busca de conteúdos: www.nv1c.com Referências 1. National Institute of Environmental Health Sciences. https://x.gd/qL4kp 2. Casals-Casas C, Desvergne B. Endocrine disruptors: from endocrine to metabolic disruption. Annu Rev Physiol. 2011. doi:10.1146/annurev-physiol-012110-142200 3. Kahn LG, et al Endocrine-disrupting chemicals: implications for human health. Lancet Diabetes Endocrinol. 2020. doi:10.1016/S2213-8587(20)30129-7 4. Patisaul HB, Jefferson W. The pros and cons of phytoestrogens. Front Neuroendocrinol. 2010. doi:10.1016/j.yfrne.2010.03.003 5. Johns Hopkins. Anatomy of the Endocrine System. https://x.gd/X91ES 6. La Merrill MA, et al. Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification. Nat Rev Endocrinol. 2020. doi:10.1038/s41574-019-0273-8 7. Willyard C. Girls are starting puberty younger - why, and what are the risks?. Nature. 2026. doi:10.1038/d41586-026-00089-8 8. Uldbjerg CS, et al. Prenatal and postnatal exposures to endocrine disrupting chemicals and timing of pubertal onset in girls and boys: a systematic review and meta-analysis. Hum Reprod Update. 2022. doi:10.1093/humupd/dmac013 9. Lopez-Rodriguez D, et al. Endocrine-disrupting chemicals and their effects on puberty. Best Pract Res Clin Endocrinol Metab. 2021. doi:10.1016/j.beem.2021.101579 10. Castiello F, Freire C. Exposure to non-persistent pesticides and puberty timing: a systematic review of the epidemiological evidence. Eur J Endocrinol. 2021. doi:10.1530/EJE-20-1038 11. Levine H, et al. Temporal trends in sperm count: a systematic review and meta-regression analysis. Hum Reprod Update. 2017. doi:10.1093/humupd/dmx022 12. Martenies SE, Perry MJ. Environmental and occupational pesticide exposure and human sperm parameters: a systematic review. Toxicology. 2013. doi:10.1016/j.tox.2013.02.005 13. Knapke ET, et al. Environmental and occupational pesticide exposure and human sperm parameters: A Navigation Guide review. Toxicology. 2022. doi:10.1016/j.tox.2021.153017 14. Martínez MÁ, et al. Lack of association between endocrine disrupting chemicals and male fertility: A systematic review and meta-analysis. Environ Res. 2023. doi:10.1016/j.envres.2022.114942 15. Agência Nacional de Vigilância Sanitária – ANVISA. Bisfenol A. https://www.gov.br/anvisa/pt-br/setorregulado/regularizacao/alimentos/bisfenol-a 16. Endocrine Society. What you can do about EDCs. https://x.gd/fIToO 17. Sociedade Brasileira de Endocrinologia e Metabologia do Estado de São Paulo. Desreguladores endócrinos: como minimizar riscos. https://x.gd/LGVQl 18. Zhang X, et al. Global prevalence and incidence of precocious puberty: a systematic review and meta-analysis. BMC Public Health. 2025. doi: 10.1186/s12889-025-25723-4. 19. Wang Y, et al. Risk factors for precocious puberty: A systematic review and meta‑analysis. Psychoneuroendocrinology. 2025. doi: 10.1016/j.psyneuen.2025.107427 20. Mazur, Witold. 11 Phytoestrogen content in foods. Baillière's Clinical Endocrinology and Metabolism, 1998. doi:10.1016/s0950-351x(98)80013-x 21. Shin MY, et al. Pharmacokinetic profile of propyl paraben in humans after oral administration. Environ Int. 2019. doi: 10.1016/j.envint.2019.104917 22. Shin MY, et al. Pharmacokinetics of transdermal methyl-, ethyl-, and propylparaben in humans following single dermal administration. Chemosphere. 2023. doi: 10.1016/j.chemosphere.2022.136689 23. Isaac, R.A.A, et al. Human endocrine disruption: an updated review of toxicological insights into parabens and phthalates. Toxicol. Environ. Health Sci. 2025. doi: 10.1007/s13530-025-00264-w 24. Safety Assessment of Dibutyl Phthalate, Diethyl Phthalate, and Dimethyl Phthalate as Used in Cosmetics. Cosmetic Ingredient Review, 2025. Disponível em: https://x.gd/lnTpC 25. Sharma L, Daley SF. Precocious Puberty. [Updated 2025 Nov 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://x.gd/VmlfH 26. https://youtu.be/h5Ta6T2DmRQ?si=-SdlEeJYdRNEVXTm 27. https://youtu.be/2DVcs9kP97s?si=G-LlHN0DU_TJJRCE 28. Venkatesh, KP et al. US Food and Drug Administration recalls of cosmetic and personal products from 2011 to 2023: A cross-sectional study. JAAD, 2025. DOI: 10.1016/j.jaad.2024.09.040 29. Publicações RIFM: https://x.gd/XLi8xd 30. Puberdade precoce. Sociedade Brasileira de Pediatria, 2023. Disponível em: https://x.gd/LNt2WB