Why Some Brains Stay Sharp Despite Amyloid: The NAD Resilience Factor

LINK: https://staycuriousmetabolism.substack.com/p/never-get-alzheimers-disease-the?r=40ekz2 Alzheimer’s disease is typically framed as a problem of amyloid plaques—but emerging research suggests impaired brain energy metabolism may be a critical and underappreciated factor. Although amyloid accumulates in many people, many remain cognitively normal, pointing to potential biological 'resilience' mechanisms. One candidate is NAD, a central metabolic co-factor involved in cellular energy production; in animal models, restoring NAD has been shown to prevent—and in some cases reverse—Alzheimer’s-related changes. This isn’t proof of a treatment in humans—but it highlights why targeting brain energy biology, including lifestyle approaches such as exercise and dietary compounds that influence NAD pathways, deserves serious scientific attention. This is the short version—see the full deep dive for context, mechanisms, and limitations. #Alzheimers #BrainHealth #NAD #Neuroscience #BrainMetabolism #DementiaResearch #ExerciseScience #HealthyAging #MetabolicHealth #StayCurious