50% IVF Failures Happen Because of This… - Dr. Seema Manjunath | Doctors' Circle

🌐https://www.cloudninefertility.com/doctors/dr-seema-bevahalli-ramakrishnappa 🌐https://www.cloudninecare.com/doctors/dr-seema-bevahalli-ramakrishnappa 📞 +91 99728 99728 (Online & in-person appointment can be booked online or by call) 📧 [email protected] 🌐https://www.cloudninecare.com/centre/thanisandra Cloudnine Hospitals, Thanisandra, Bangalore Recurrent implantation failure is when the transferred embryos fail to implant after having multiple IVF cycles. Now, implantation is the first step in the cross-talk between the embryo and the endometrium for a successful pregnancy. RIF is a complex phenomenon where there are multiple factors that affect the implantation. It could include the male factors, the female factors, or the embryo factors. Hence, the evaluation is likewise. Coming to the male factor evaluation, the first and foremost is the evaluation of the semen parameters. The next step is doing the DNA fragmentation index of the sperm, karyotyping, and also ruling out any comorbidities associated with the male factor. Now, coming to the female factor, let's go anatomically. Coming to the uterus, we need to do a 3D pelvic scan, and it can also be added with hysteroscopy with biopsy or immunohistochemistry. Now, why we need to do all these things is to rule out any conditions like polyps or adenomyosis or fibroids in the uterus, or if there are any developmental defects in the uterus, like a subseptate or septate uterus. Next is to evaluate your ovaries. You need to check for the ovarian reserve. To do that, you need to do an anti-Müllerian hormone analysis. Also, if there is any endometriosis associated, you need to check that. Now, coming to the tubes, see if there is any hydrosalpinx in the tubes or endometriosis or any tuberculosis history. You rule out all these things. Also, in the uterus, you need to evaluate to see if there is any shift in the window of implantation. This can be tested by a test known as the endometrial receptivity assay, where we can identify if there is any shift in the embryo age and the endometrial age. Coming to immunology, you have to check for antibodies. APAs screening to be done, or if there are any acquired immunological conditions like SLE, you have to rule this out. Then the final factor is the embryo factor. You have to check whether the embryo is euploid or not. In 50 to 70% of the cases, it's mainly because of the embryo abnormalities. Even if the embryos are looking Grade A, nearly 40% of those embryos could be genetically abnormal. Even after evaluating all these things, in nearly 10 to 15% of couples, the cause cannot be identified, and these couples are known as idiopathic. recurrent implantation failure | IVF failure reasons | why IVF fails repeatedly | repeated IVF failure causes | good embryo no implantation | grade A embryo failed to implant | IVF not working what next | implantation failure treatment | causes of failed embryo transfer | endometrial receptivity test | ERA test IVF | embryo quality problems | sperm DNA fragmentation IVF | karyotype test infertility | hydrosalpinx IVF failure | adenomyosis implantation failure | endometriosis IVF success rate #doctorscircle #cloudnine #cloudninehospitals #weknowmoms #RecurrentImplantationFailure #IVFFailure #IVFJourney #EmbryoTransfer #ImplantationFailure #IVFSupport #FertilityTreatment #InfertilityAwareness