Statins and Weight Gain: The Mechanism Most People Miss

LINK: https://open.substack.com/pub/staycuriousmetabolism/p/do-statins-cause-weight-gain-its?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true A meta-analysis of randomized controlled trials shows that statins are associated with a small but real increase in weight—an effect that could compound over time. Mechanistically, statins can lower key metabolic hormones such as leptin and GLP-1, and inhibition of HMG-CoA reductase itself has been linked to weight gain and insulin resistance. In other words, the same pathway used to lower cholesterol may also contribute to this side effect. For the full mechanisms, limitations, and clinical nuance, watch the long-form deep dive linked above. #Statins #WeightGain #MetabolicHealth #Cholesterol #ClinicalResearch #ScienceExplained